Research Data

REFERENCES: Andrographis Paniculata

"Antioxidant and anti-inflammatory activities of the plant Andrographis paniculata Nees." Immonopharmacol Immunotoxicol, 2006;28(1):129-140. Amala Cancer Research Centre, Thrissur, Kerala, India.

Caceres DD, Hancke JL, Burgos RA, et al. "Use of visual analogue scale measurements to assess the effectiveness of standardized Andrographis paniculata extract in reducing the symptoms of common cold. A randomized double-blind placebo study. "Phytomedicine, 1999;6(4):217-223.

Caceres DD, Hancke JL, Burgos RA, et al. "Prevention of common colds with Andrographis paniculata dried extract." Phytomedicine, 1997;4(2):101-104.

Coon JT, Erenst E. "Androraphis paniculata in the Treatment of Upper Respiratory tract Infections: A Systematic Review of Safety and Efficacy." Planta Med, 2004:70:293-298.

Gabrielian ES, Shukarian AK, Goukasova GI, et al. "A double-blind placebo-controlled study of Andrographis paniculata fixed combinations Kan Jang in the treatment of acute respiratory tract infections including sinusitis." Phytomedicine, 2002;9(7):589-597.

Hancke J, Burgos R, Caceres D, and Wilkman G. "A Double-blind Study with a New Monodrug KanJang: Decrease of Symptoms and Improvements in the Recovery from Common Colds." Phytother Res, 1995;9:559-562.

Kulichenko LL, Kireyeva LV, Malyshkina EN, et al. "A randomized, controlled study of Kan Jang versus amantadine in the treatment of influenza in Volgograd." J Herb Pharmacother, 2003;3(1):77-93.

Kumar RA, Sridevi K, Kumar NV, et al. "Anticancer and immunostimulatory compounds from Andrographis paniculata." J Ethnopharmacol, 2004 June;92(2-3):291.

MelchiorJ, Palm S, Wikman G. "Controlled clinical study of standardized Andrographis paniculata extract in common colds - a pilot trial." Phytomedicine 1996;3:314-318.

Melchior J, Spasov AA, Ostovskij OV, et al. "Double-blind, placebo-controlled pilot and phase III study of activity of standardized Andrographis paniculata Herba Nees extract fixed combination (Kan jang) in the treatment of uncomplicated upper-respiratory tract infection." Phytomedicine, 2000;7(5): 341-364.

Poolsup N, Suthisisang C, Prathanturarug S, et al. "Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials." J Clin Pharm Ther 2004;29(1):37-45.

Prajjal K. Singha, S. Roy and S. Dey, "Antimicrobial activity of Andrographis paniculata." Fitoterapia Volume 74, issues 7-8, December 2003: 692-694.

Puri A, Saxena R, Saxena RP, Saxena KC, Srivastava V, Tandon JS. "Immunostimulant agents from Andrographis paniculata." J Nat Prod. 1993 Jul;56(7):995-9.

Shen YC, Chen CF, Chiou WF. "Andrographolide prevents oxygen radical production by human neutrophils, possible mechanism(s) involved in its anti-inflammatory effect." Br J Pharmacol 2002;135(2):399-406.

Thamlikitkul V, et al. "Efficacy of Andrographis paniculata (Nees) for pharyngotonsillitis in adults." J Med Assoc Thai 1991;74(10): 437-442, 1991.

REFERENCES: Astralagus Membranaceus

Anon. "Astralagus membranaceus. Monograph." Alternative Medicine Review. 2003; 8(1): 72-77.

Cho WC, Leung KN. "In vitro and in vivo immunomodulating and immunorestorative effects of Astralagus membranaceus." Journal of Ethnopharmacology. 2007; 113 (1) 132-141.

Chu DT, Wong WL, Mavaligit GM. "Immunotherapy with Chinese medicinal herbs. II. Reversal of cyclophosphamide-induced immune suppression by administration of fractionated Astralagus membranaceus in vivo." J Clin Lab Immunol. 1988b; 25(3): 125-129.

Peng T, Yang Y, Rieseman H, Kandolf R. "The inhibitory effect of Astralagus membranaceus on coxsackie B-3 virus RNA replication." Chin Med Sci J. 1995; 10(3): 146-150.

Sun Y, Yang J. "Experimental study of the effect of Astralagus membranaceus against herpes simplex virus type 1." Di Yi Jun Yi Da Xue Xue Bao. 2004; (1): 57-58.

Tan BK, Vanitha J. "Immunomodulatory and antimicrobial effects of some traditional chinese medicinal herbs: a review." Curr Med Chem. 2004 Jun; 11(11):1423-1430.

Zhou KS, Mancini C, Doria G. "Enhancement of the immune response in mice by Astralagus membranaceus extracts." Immunopharmacology. 1990 Nov-Dec; 20(3):225-233.

REFERENCES: Panax Quinquefolium

Assinewe VA, Amason JT, Aubry A, Mullin J, Lemaire I. "Extractable polysaccharides of Panax quinquefolius L. (North American ginseng) root stimulate TNF alpha production by alveolar macrophages." Phytomedicine 2002 Jul; 9(5): 398-404.

McElhaney JE, Gravenstein S, Cole SK, et al. "A placebo-controlled trial of a proprietary extract of North American ginseng (CVT-E002) to prevent acute respiratory illness in institutionalized older adults." J Am Geriatr Soc 2004 Jan; 52(1): 13-19.

Wang M, Guilbert LJ, Li J, Wu Y, Pang P, Basu TK, Shan JJ. "A proprietary extract from North American ginseng (Panax quinquefolium) enhances IL-2 and IFN-gamma productions in murine spleen cells induced by Con-A." Int Immunopharmacol 2004 Feb: 4(2): 311-315.

Wang M, Guilbert LJ, Lin L, et al. "Immunomodulating activity of CVT-E002, a proprietary extract from North American ginseng (Panax quinquefolium)." J Pharm Pharmacol 2001 Nov; 53(11): 1515-1523.

REFERENCES: Pelargonium Sidoides

Bereznoy VV, Riley DS, Wassmer G, Heger M. "Efficacy of extract of Pelargonium sidoides in children with acute non-group A beta-hemolytic streptococcus tonsillopharyngitis: a randomized, double-blind, placebo-controlled trial." Altern Ther Health Med. 2003 Sept-Oct; 9: 68-79.

Bladt S, Wagner H. "From Zulu medicine to the European phytomedicine Umckaloabo." Phytomedicine 2007; 14(1): 2-4.

Chuchalin AG, Berman B, Lehmacher W. "Treatment of acute bronchitis in audluts with a Pelargonium sidoides preparation (EPs 7630): a randomized, double-blind, placebo-controlled trial." Explore (NY). 2005; 1: 437-445.

Kolodziej H, Kiderlen AF. "In vitro evaluation of antibacterial and immunomodulatory activities of Pelargonium reniforme, Pelargonium sidoides, and the related herbal drug preparation EPs 7630." Phytomedicine 2007; 14(1): 18-26.

Lizogub V, Riley D, Heer M. "Efficacy of a Pelaronium Sidoides preparation in patients with the common cold: A randomized, double blind, placebo-controlled clinical trial." EXPLORE (NY): The Journal of Science and Healing; 2007; 3(6): 573-584.

Matthys H, Eisebitt R, Seith B, Heger M. "Efficacy and safety of an extract of Pelargonium sidoides (Eps 7630) in adults with acute bronchitis. A randomized, double-blind, placebo-controlled trial." Phytomedicine. 2003; 10(4): 7-17.

Matthy H, Heger M. "Treatment of acute bronchitis with a liquid herbal drug preparation from Pelargonium sidoides (EPs 7630): a randomized, double-blind, placebo-controlled, multicentre study." Curr Med Res Opin. 2007; 23: 3233-331.

Matthys H, Kamin W, Funk P, Heger M. "Pelargonium sidoides preparation (EPs 7630) in the treatment of acute bronchitis in adults and children." Phytomedicine. 2007;14(6): 69-73.

Timmer A, Gunther J, Rucker G, Motschall E, Antes G, Kern WV. "Pelargonium sidoides extract for acute respiratory tract infections." Cochrane Database Syst Rev. 2008(3): CD006323.

REFERENCES: Sambucus Nigra

Barak V, Bbirkenfeld S, Halperin T, Kalickman I. "The effect of herbal remedies on the production of human inflammatory and anti-inflammatory cytokines." Isr Med Assoc J. 2002; 4: S919-S922.

Barak V, Halperin T, Kalickman I. "The effect of Sambucol ®, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw. 2001; 12:290-296.

Craig, Winston J. "Elderberry: nature's powerful cold-and flu-symptom suppressor." Vibrant Life. Nov 1, 2005.

Maurer, R. "Elderberry extract: new research demonstrates reduction in the duration of the flu." Original Internist. March 1, 2004.

Morag AM, Mumcuoglu M, Baybikov T, et al. ""Inhibition of sensitive and acyclovir-resistant HSV-1 strains by an elderberry extract in vitro." Z Phytother. 1997; 25:97-98.

Mumcuoglu M. "Sambucus nira (L), Black Elderberry Extract: A breakthrough in the treatment of influenza." Skokie, Illinois: RSS Publishing, 1995.

Youdim KA, Martin A, Joseph JA. "Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress." Free Radic Biol Med. 2000; 29: 51-60.

Zakay-Rones Z, Thorn E, Wollan T, Wadstein J. "Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections." J Int Med Res. 2004; 32:132-140.

Zakay-Rones z, Varsano N, Zlotnik M, Manor O, et al. "Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B in Panama." Journal of Alternative and Complementary Medicine. 1995; 1(4): 361-369.